Reduced in vivo mutagenesis by mutant herpes simplex DNA polymerase involves improved nucleotide selection.

We present evidence that mutation frequencies in a mammalian system can vary according to the replication fidelity of the DNA polymerase. We demonstrated previously that several derivatives of herpes simplex virus type 1 that encode polymerases resistant to various antiviral drugs (e.g., nucleotide...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Hall, J D, Furman, P A, St Clair, M H, Knopf, C W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1985
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397894/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2987953/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.11.3889
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