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Cyp26 enzymes are required to balance the cardiac and vascular lineages within the anterior lateral plate mesoderm
Normal heart development requires appropriate levels of retinoic acid (RA) signaling. RA levels in embryos are dampened by Cyp26 enzymes, which metabolize RA into easily degraded derivatives. Loss of Cyp26 function in humans is associated with numerous developmental syndromes that include cardiovasc...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Company of Biologists
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3978838/ https://ncbi.nlm.nih.gov/pubmed/24667328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.105874 |
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