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Cyp26 enzymes are required to balance the cardiac and vascular lineages within the anterior lateral plate mesoderm

Normal heart development requires appropriate levels of retinoic acid (RA) signaling. RA levels in embryos are dampened by Cyp26 enzymes, which metabolize RA into easily degraded derivatives. Loss of Cyp26 function in humans is associated with numerous developmental syndromes that include cardiovasc...

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Detalles Bibliográficos
Main Authors: Rydeen, Ariel B., Waxman, Joshua S.
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists 2014
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978838/
https://ncbi.nlm.nih.gov/pubmed/24667328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.105874
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