KRAS Protein Stability Is Regulated through SMURF2: UBCH5 Complex-Mediated β-TrCP1 Degradation

Attempts to target mutant KRAS have been unsuccessful. Here, we report the identification of Smad ubiquitination regulatory factor 2 (SMURF2) and UBCH5 as a critical E3:E2 complex maintaining KRAS protein stability. Loss of SMURF2 either by small interfering RNA/short hairpin RNA (siRNA/shRNA) or by...

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Hauptverfasser: Shukla, Shirish, SankarAllam, Uday, Ahsan, Aarif, Chen, Guoan, Krishnamurthy, Pranathi Meda, Marsh, Katherine, Rumschlag, Matthew, Shankar, Sunita, Whitehead, Christopher, Schipper, Matthew, Basrur, Venkatesha, Southworth, Daniel R, Chinnaiyan, Arul M, Rehemtulla, Alnawaz, Beer, David G, Lawrence, Theodore S, Nyati, Mukesh K, Ray, Dipankar
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press Inc. 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978392/
https://ncbi.nlm.nih.gov/pubmed/24709419
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