The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression

The transcription factor E4bp4 (Nfil3) is essential for natural killer (NK) cell production. Here, we show that E4bp4 is required at the NK lineage commitment point when NK progenitors develop from common lymphoid progenitors (CLPs) and that E4bp4 must be expressed at the CLP stage for differentiati...

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Hlavní autoři: Male, Victoria, Nisoli, Ilaria, Kostrzewski, Tomasz, Allan, David S.J., Carlyle, James R., Lord, Graham M., Wack, Andreas, Brady, Hugh J.M.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2014
Témata:
Brief Definitive Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978281/
https://ncbi.nlm.nih.gov/pubmed/24663216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20132398
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