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Modulation of the Human T Cell Response by a Novel Non-Mitogenic Anti-CD3 Antibody

The agonistic anti-human CD3ε antibody (Ab), OKT3, has been used to control acute transplant rejection. The in vivo administration of OKT3 was previously shown to induce the partial depletion of T cells and unresponsiveness (anergy) in the remaining CD4(+) T cells. However, this therapy is also asso...

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Autors principals: Shiheido, Hirokazu, Chen, Chen, Hikida, Masaki, Watanabe, Takeshi, Shimizu, Jun
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978038/
https://ncbi.nlm.nih.gov/pubmed/24710513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094324
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