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Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities
ROCK1 and ROCK2 mediate important processes such as cell migration, invasion and metastasis; making them good targets for the development of antitumor agents. Recently, using a fragment-based approach and X-ray crystallography, we reported on the design and synthesis of novel Rho-kinase inhibitors (...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3977753/ https://ncbi.nlm.nih.gov/pubmed/23396364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.634 |
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