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Chk1 keeps cell cycle transcription active in response to replication stress by interfering with E2F6-dependent repression
BACKGROUND: In eukaryotic cells, detection of replication stress results in the activation of the DNA replication checkpoint, a signaling cascade whose central players are the kinases ATR and Chk1. The checkpoint response prevents the accumulation of DNA damage and ensures cell viability by delaying...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3977652/ https://ncbi.nlm.nih.gov/pubmed/23954429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2013.06.063 |
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