Chk1 keeps cell cycle transcription active in response to replication stress by interfering with E2F6-dependent repression

BACKGROUND: In eukaryotic cells, detection of replication stress results in the activation of the DNA replication checkpoint, a signaling cascade whose central players are the kinases ATR and Chk1. The checkpoint response prevents the accumulation of DNA damage and ensures cell viability by delaying...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Bertoli, Cosetta, Klier, Steffi, McGowan, Clare, Wittenberg, Curt, de Bruin, Robertus A. M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977652/
https://ncbi.nlm.nih.gov/pubmed/23954429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2013.06.063
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