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Improvement of HIV fusion inhibitor C34 efficacy by membrane anchoring and enhanced exposure

OBJECTIVES: The aim of the present work was to evaluate the interaction of two new HIV fusion inhibitors {HIVP3 [C34–polyethylene glycol (PEG)(4)–cholesterol] and HIVP4 [(C34–PEG(4))(2)–cholesterol]} with membrane model systems and human blood cells in order to clarify where and how the fusion inhib...

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Autors principals: Augusto, Marcelo T., Hollmann, Axel, Castanho, Miguel A. R. B., Porotto, Matteo, Pessi, Antonello, Santos, Nuno C.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977611/
https://ncbi.nlm.nih.gov/pubmed/24464268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkt529
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