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Putative role of membranes in the HIV fusion inhibitor enfuvirtide mode of action at the molecular level.
Partition of the intrinsically fluorescent HIV fusion inhibitor enfuvirtide into lipidic membranes is relatively high (Delta G =6.6 kcal x mol(-1)) and modulated by cholesterol. A shallow position in the lipidic matrix makes it readily available for interaction with gp41. No conformational energetic...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1223848/ https://ncbi.nlm.nih.gov/pubmed/14514352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031350 |
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