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Putative role of membranes in the HIV fusion inhibitor enfuvirtide mode of action at the molecular level.

Partition of the intrinsically fluorescent HIV fusion inhibitor enfuvirtide into lipidic membranes is relatively high (Delta G =6.6 kcal x mol(-1)) and modulated by cholesterol. A shallow position in the lipidic matrix makes it readily available for interaction with gp41. No conformational energetic...

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Bibliografski detalji
Glavni autori: Veiga, Salomé, Henriques, Sónia, Santos, Nuno C, Castanho, Miguel
Format: Artigo
Jezik:Inglês
Izdano: 2004
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223848/
https://ncbi.nlm.nih.gov/pubmed/14514352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031350
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