Population pharmacokinetics of rifampicin, pyrazinamide and isoniazid in children with tuberculosis: in silico evaluation of currently recommended doses

OBJECTIVES: To describe the population pharmacokinetics of rifampicin, pyrazinamide and isoniazid in children and evaluate the adequacy of steady-state exposures. PATIENTS AND METHODS: We used previously published data for 76 South African children with tuberculosis to describe the population pharma...

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Hauptverfasser: Zvada, Simbarashe P., Denti, Paolo, Donald, Peter R., Schaaf, H. Simon, Thee, Stephanie, Seddon, James A., Seifart, Heiner I., Smith, Peter J., McIlleron, Helen M., Simonsson, Ulrika S. H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977610/
https://ncbi.nlm.nih.gov/pubmed/24486870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkt524
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