Pharmacokinetics of a CCR5 inhibitor in rhesus macaques following vaginal, rectal and oral application

OBJECTIVES: This study measured and compared the pharmacokinetics of CMPD167, a small molecule antiretroviral CCR5 inhibitor with potential as an HIV microbicide, following vaginal, rectal and oral administration in rhesus macaques. METHODS: A vaginal hydroxyethylcellulose (HEC) gel, a rectal HEC ge...

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Autors principals: Malcolm, R. Karl, Lowry, Deborah, Boyd, Peter, Geer, Leslie, Veazey, Ronald S., Goldman, Laurie, Klasse, P. J., Shattock, Robin J., Moore, John P.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
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Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977607/
https://ncbi.nlm.nih.gov/pubmed/24381072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkt506
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