Quantification of Transthyretin Kinetic Stability in Human Plasma Using Subunit Exchange

[Image: see text] The transthyretin (TTR) amyloidoses are a group of degenerative diseases caused by TTR aggregation, requiring rate-limiting tetramer dissociation. Kinetic stabilization of TTR, by preferential binding of a drug to the native tetramer over the dissociative transition state, dramatic...

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Hauptverfasser: Rappley, Irit, Monteiro, Cecília, Novais, Marta, Baranczak, Aleksandra, Solis, Gregory, Wiseman, R. Luke, Helmke, Stephen, Maurer, Mathew S., Coelho, Teresa, Powers, Evan T., Kelly, Jeffery W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977577/
https://ncbi.nlm.nih.gov/pubmed/24661308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500171j
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