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Aβ-induced Golgi fragmentation in Alzheimer’s disease enhances Aβ production

Golgi fragmentation occurs in neurons of patients with Alzheimer’s disease (AD), but the underlying molecular mechanism causing the defects and the subsequent effects on disease development remain unknown. In this study, we examined the Golgi structure in APPswe/PS1∆E9 transgenic mouse and tissue cu...

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Detalhes bibliográficos
Main Authors: Joshi, Gunjan, Chi, Youjian, Huang, Zheping, Wang, Yanzhuang
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977293/
https://ncbi.nlm.nih.gov/pubmed/24639524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320192111
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