TNFR1/Phox Interaction and TNFR1 Mitochondrial Translocation Thwart Silica-Induced Pulmonary Fibrosis

Macrophages play a fundamental role in innate immunity and the pathogenesis of silicosis. Phagocytosis of silica particles is associated with the generation of reactive oxygen species (ROS), secretion of cytokines, such as TNF, and cell death that contribute to silica-induced lung disease. In macrop...

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Detalhes bibliográficos
Main Authors: Fazzi, Fabrizio, Njah, Joel, Di Giuseppe, Michelangelo, Winnica, Daniel E., Go, Kristina, Sala, Ernest, St Croix, Claudette M., Watkins, Simon C., Tyurin, Vladimir A., Phinney, Donald G., Fattman, Cheryl L., Leikauf, George D., Kagan, Valerian E., Ortiz, Luis A.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2014
Assuntos:
Innate Immunity and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977215/
https://ncbi.nlm.nih.gov/pubmed/24623132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1103516
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