TNFR1/Phox Interaction and TNFR1 Mitochondrial Translocation Thwart Silica-Induced Pulmonary Fibrosis

Macrophages play a fundamental role in innate immunity and the pathogenesis of silicosis. Phagocytosis of silica particles is associated with the generation of reactive oxygen species (ROS), secretion of cytokines, such as TNF, and cell death that contribute to silica-induced lung disease. In macrop...

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Autors principals: Fazzi, Fabrizio, Njah, Joel, Di Giuseppe, Michelangelo, Winnica, Daniel E., Go, Kristina, Sala, Ernest, St Croix, Claudette M., Watkins, Simon C., Tyurin, Vladimir A., Phinney, Donald G., Fattman, Cheryl L., Leikauf, George D., Kagan, Valerian E., Ortiz, Luis A.
Format: Artigo
Idioma:Inglês
Publicat: AAI 2014
Matèries:
Innate Immunity and Inflammation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977215/
https://ncbi.nlm.nih.gov/pubmed/24623132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1103516
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