TNFR1/Phox Interaction and TNFR1 Mitochondrial Translocation Thwart Silica-Induced Pulmonary Fibrosis

Macrophages play a fundamental role in innate immunity and the pathogenesis of silicosis. Phagocytosis of silica particles is associated with the generation of reactive oxygen species (ROS), secretion of cytokines, such as TNF, and cell death that contribute to silica-induced lung disease. In macrop...

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Bibliographische Detailangaben
Hauptverfasser: Fazzi, Fabrizio, Njah, Joel, Di Giuseppe, Michelangelo, Winnica, Daniel E., Go, Kristina, Sala, Ernest, St Croix, Claudette M., Watkins, Simon C., Tyurin, Vladimir A., Phinney, Donald G., Fattman, Cheryl L., Leikauf, George D., Kagan, Valerian E., Ortiz, Luis A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: AAI 2014
Schlagworte:
Innate Immunity and Inflammation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977215/
https://ncbi.nlm.nih.gov/pubmed/24623132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1103516
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