DNA methylation of E-cadherin is a priming mechanism for prostate development

In prostate and other epithelial cancers, E-cadherin (CDH1) is downregulated inappropriately by DNA methylation to promote an invasive phenotype. Though cancer frequently involves a reawakening of developmental signaling pathways, whether DNA methylation of Cdh1 occurs during organogenesis has not b...

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Autori principali: Keil, Kimberly P., Abler, Lisa L., Mehta, Vatsal, Altmann, Helene M., Laporta, Jimena, Plisch, Erin H., Suresh, M., Hernandez, Laura L., Vezina, Chad M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976955/
https://ncbi.nlm.nih.gov/pubmed/24503032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2014.01.020
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