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Methods of Designing Two-stage Winner Trials with Survival Outcomes
In drug development, especially for oncology studies, a recent proposal is to combine a costly phase II dose selection study with a subsequent phase III study into a single trial that compares the selected (winning) dose from the first stage with the control group. This design may also be used in ph...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3976764/ https://ncbi.nlm.nih.gov/pubmed/24347247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6070 |
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