K63-linked polyubiquitylation of IRF1 transcription factor is essential for IL-1-induced CCL5 and CXCL10 chemokine production

Although interleukin-1 (IL-1) induces expression of interferon regulatory factor 1 (IRF1), its roles in immune and inflammatory responses and mechanisms of activation remain elusive. Here, we show that IRF1 is essential for IL-1-induced expression of chemokines CXCL10 and CCL5 that recruit mononucle...

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Autori principali: Harikumar, Kuzhuvelil B., Yester, Jessie W., Surace, Michael J., Oyeniran, Clement, Price, Megan M., Huang, Wei-Ching, Hait, Nitai C., Allegood, Jeremy C., Yamada, Akimitsu, Kong, Xiangqian, Lazear, Helen M., Bhardwaj, Reetika, Takabe, Kazuaki, Diamond, Michael S., Luo, Cheng, Milstien, Sheldon, Spiegel, Sarah, Kordula, Tomasz
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976678/
https://ncbi.nlm.nih.gov/pubmed/24464131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2810
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