Effect of Bortezomib on the Efficacy of AAV9.SERCA2a Treatment to Preserve Cardiac Function in a Rat Pressure-Overload Model of Heart Failure

Adeno-associated virus (AAV)-based vectors are promising vehicles for therapeutic gene delivery, including for the treatment of heart failure. It has been demonstrated for each of the AAV serotypes 1 through 8 that inhibition of the proteasome results in increased transduction efficiencies. For AAV9...

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Autori principali: Chaanine, Antoine H., Nonnenmacher, Mathieu, Kohlbrenner, Erik, Jin, Dongzhu, Kovacic, Jason C., Akar, Fadi G., Hajjar, Roger J., Weber, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976435/
https://ncbi.nlm.nih.gov/pubmed/24572786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2014.7
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