Fine mapping of the celiac disease-associated LPP locus reveals a potential functional variant

Using the Immunochip for genotyping, we identified 39 non-human leukocyte antigen (non-HLA) loci associated to celiac disease (CeD), an immune-mediated disease with a worldwide frequency of ∼1%. The most significant non-HLA signal mapped to the intronic region of 70 kb in the LPP gene. Our aim was t...

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Hlavní autoři: Almeida, Rodrigo, Ricaño-Ponce, Isis, Kumar, Vinod, Deelen, Patrick, Szperl, Agata, Trynka, Gosia, Gutierrez-Achury, Javier, Kanterakis, Alexandros, Westra, Harm-Jan, Franke, Lude, Swertz, Morris A., Platteel, Mathieu, Bilbao, Jose Ramon, Barisani, Donatella, Greco, Luigi, Mearin, Luisa, Wolters, Victorien M., Mulder, Chris, Mazzilli, Maria Cristina, Sood, Ajit, Cukrowska, Bozena, Núñez, Concepción, Pratesi, Riccardo, Withoff, Sebo, Wijmenga, Cisca
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
Association Studies Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976328/
https://ncbi.nlm.nih.gov/pubmed/24334606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt619
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