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Nuclear Translocation and Regulation of Intranuclear Distribution of Cytoplasmic Poly(A)-Binding Protein Are Distinct Processes Mediated by Two Epstein Barr Virus Proteins

Many viruses target cytoplasmic polyA binding protein (PABPC) to effect widespread inhibition of host gene expression, a process termed viral host-shutoff (vhs). During lytic replication of Epstein Barr Virus (EBV) we observed that PABPC was efficiently translocated from the cytoplasm to the nucleus...

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Detalhes bibliográficos
Main Authors: Park, Richard, El-Guindy, Ayman, Heston, Lee, Lin, Su-Fang, Yu, Kuan-Ping, Nagy, Mate, Borah, Sumit, Delecluse, Henri-Jacques, Steitz, Joan, Miller, George
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976295/
https://ncbi.nlm.nih.gov/pubmed/24705134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092593
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