Pancreatic Alpha-Cell Dysfunction Contributes to the Disruption of Glucose Homeostasis and Compensatory Insulin Hypersecretion in Glucocorticoid-Treated Rats

Glucocorticoid (GC)-based therapies can cause insulin resistance (IR), glucose intolerance, hyperglycemia and, occasionally, overt diabetes. Understanding the mechanisms behind these metabolic disorders could improve the management of glucose homeostasis in patients undergoing GC treatment. For this...

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Main Authors: Rafacho, Alex, Gonçalves-Neto, Luiz M., Santos-Silva, Junia C., Alonso-Magdalena, Paloma, Merino, Beatriz, Taboga, Sebastião R., Carneiro, Everardo M., Boschero, Antonio C., Nadal, Angel, Quesada, Ivan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976288/
https://ncbi.nlm.nih.gov/pubmed/24705399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093531
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