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A novel Death Defying Domain in Met entraps the active site of Caspase-3 and blocks apoptosis in hepatocytes
Met, the transmembrane tyrosine kinase receptor for hepatocyte growth factor (HGF) is known to function as a potent anti-apoptotic mediator in normal and neoplastic cells. Herein we report that intracellular cytoplasmic tail of Met has evolved to harbor a tandem pair of Caspase-3 cleavage sites, whi...
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| Hlavní autoři: | , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3975826/ https://ncbi.nlm.nih.gov/pubmed/24122846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26769 |
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