Metabolic activation of the nucleoside analog 9-[( 2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human diploid fibroblasts infected with human cytomegalovirus.

9-[( 2-Hydroxy-1-(hydroxymethyl)ethoxy]-methyl)guanine (BW B759U) is a more potent inhibitor of human cytomegalovirus (HCMV) in vitro than is the related nucleoside analog acyclovir (ACV). BW B759U was selectively activated to the 5'-triphosphate (BW B759U-triphosphate) in cells infected with HCMV t...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Biron, K K, Stanat, S C, Sorrell, J B, Fyfe, J A, Keller, P M, Lambe, C U, Nelson, D J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1985
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397581/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2986118/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.8.2473
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