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Lysosomotropic agents selectively potentiate thrombin-induced acid hydrolase secretion from platelets.

Thrombin induces partial secretion (up to 60%) of beta-N-acetyl-D-hexosaminidase (EC 3.2.1.52) from untreated platelets. Preincubation of platelets with 10 mM NH4Cl for up to 2 hr resulted in a time-dependent and marked stimulation of thrombin-induced secretion of both this enzyme and other acid gly...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Van Oost, B A, Smith, J B, Holmsen, H, Vladutiu, G D
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1985
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397560/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3157989/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.8.2374
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