Species-dependent neuropathology in transgenic SOD1 pigs

Mutations in the human copper/zinc superoxide dismutase 1 (hSOD1) gene cause familial amyotrophic lateral sclerosis (ALS). It remains unknown whether large animal models of ALS mimic more pathological events seen in ALS patients via novel mechanisms. Here, we report the generation of transgenic pigs...

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Detalhes bibliográficos
Main Authors: Yang, Huaqiang, Wang, Guohao, Sun, Haitao, Shu, Runzhe, Liu, Tao, Wang, Chuan-En, Liu, Zhaoming, Zhao, Yu, Zhao, Bentian, Ouyang, Zhen, Yang, Dongshan, Huang, Jiao, Zhou, Yueling, Li, Shihua, Jiang, Xiaodan, Xiao, Zhicheng, Li, Xiao-Jiang, Lai, Liangxue
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975503/
https://ncbi.nlm.nih.gov/pubmed/24577199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2014.25
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