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Mitofusins: ubiquitylation promotes fusion
Mitochondrial genes including Mfn2 are at the center of many diseases, underscoring their potential as a therapeutical target. The Chen group now identified 15-oxospiramilactone as a chemical inhibitor of the mammalian deubiquitylase USP30, acting on Mfn1 and Mfn2.
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| 主要作者: | |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3975502/ https://ncbi.nlm.nih.gov/pubmed/24556809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2014.23 |
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