Plasticity in salt bridge allows fusion-competent ubiquitylation of mitofusins and Cdc48 recognition

Mitofusins are dynamin-related GTPases that drive mitochondrial fusion by sequential events of oligomerization and GTP hydrolysis, followed by their ubiquitylation. Here, we show that fusion requires a trilateral salt bridge at a hinge point of the yeast mitofusin Fzo1, alternatingly forming before...

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Detalhes bibliográficos
Publicado no:Life Sci Alliance
Main Authors: Anton, Vincent, Buntenbroich, Ira, Schuster, Ramona, Babatz, Felix, Simões, Tânia, Altin, Selver, Calabrese, Gaetano, Riemer, Jan, Schauss, Astrid, Escobar-Henriques, Mafalda
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861704/
https://ncbi.nlm.nih.gov/pubmed/31740565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900491
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