12-O-Tetradecanoylphorbol-13-Acetate Induces Keratin 8 Phosphorylation and Reorganization via Expression of Transglutaminase-2

The stiffness of cancer cells is attributable to intermediate filaments such as keratin. Perinuclear reorganization via phosphorylation of specific serine residue in keratin is implicated in the deformability of metastatic cancer cells including the human pancreatic carcinoma cell line (PANC-1). 12-...

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Main Authors: Lee, Eun Ji, Park, Mi Kyung, Kim, Hyun Ji, Kang, June Hee, Kim, You Ri, Kang, Gyeoung Jin, Byun, Hyun Jung, Lee, Chang Hoon
Formato: Artigo
Idioma:Inglês
Publicado: The Korean Society of Applied Pharmacology 2014
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975474/
https://ncbi.nlm.nih.gov/pubmed/24753817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2014.007
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