Ethacrynic Acid Inhibits Sphingosylphosphorylcholine-Induced Keratin 8 Phosphorylation and Reorganization via Transglutaminase-2 Inhibition

Sphingosylphosphorylcholine (SPC) is significantly increased in the malicious ascites of tumor patients and induces perinuclear reorganization of keratin 8 (K8) filaments in PANC-1 cells. The reorganization contributes to the viscoelasticity of metastatic cancer cells resulting in increased migratio...

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Autores principales: Byun, Hyun Jung, Kang, Kyung Jin, Park, Mi Kyung, Lee, Hye Ja, Kang, June Hee, Lee, Eun Ji, Kim, You Ri, Kim, Hyun Ji, Kim, Young Woo, Jung, Kyung Chae, Kim, Soo Youl, Lee, Chang Hoon
Formato: Artigo
Lenguaje:Inglês
Publicado: The Korean Society of Applied Pharmacology 2013
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3825196/
https://ncbi.nlm.nih.gov/pubmed/24244820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2013.066
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