Restless Legs Syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon

Genome-wide association studies (GWAS) identified the MEIS1 locus for Restless Legs Syndrome (RLS), but causal single nucleotide polymorphisms (SNPs) and their functional relevance remain unknown. This locus contains a large number of highly conserved noncoding regions (HCNRs) potentially functionin...

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Détails bibliographiques
Auteurs principaux: Spieler, Derek, Kaffe, Maria, Knauf, Franziska, Bessa, José, Tena, Juan J., Giesert, Florian, Schormair, Barbara, Tilch, Erik, Lee, Heekyoung, Horsch, Marion, Czamara, Darina, Karbalai, Nazanin, von Toerne, Christine, Waldenberger, Melanie, Gieger, Christian, Lichtner, Peter, Claussnitzer, Melina, Naumann, Ronald, Müller-Myhsok, Bertram, Torres, Miguel, Garrett, Lillian, Rozman, Jan, Klingenspor, Martin, Gailus-Durner, Valérie, Fuchs, Helmut, Hrabě de Angelis, Martin, Beckers, Johannes, Hölter, Sabine M., Meitinger, Thomas, Hauck, Stefanie M., Laumen, Helmut, Wurst, Wolfgang, Casares, Fernando, Gómez-Skarmeta, Jose Luis, Winkelmann, Juliane
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2014
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975059/
https://ncbi.nlm.nih.gov/pubmed/24642863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.166751.113
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