Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia

During an ENU (N-ethyl-N-nitrosourea) mutagenesis screen, we observed a dominant small-eye mutant mouse with viable homozygotes. A corresponding mutant line was established and referred to as Aey69 (abnormality of the eye #69). Comprehensive phenotyping of the homozygous Aey69 mutants in the German...

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Detalhes bibliográficos
Publicado no:Exp Eye Res
Main Authors: Vetrivel, Sharmilee, Tiso, Natascia, Kügler, Andrea, Irmler, Martin, Horsch, Marion, Beckers, Johannes, Hladik, Daniela, Giesert, Florian, Gailus-Durner, Valerie, Fuchs, Helmut, Sabrautzki, Sibylle, Hrabě de Angelis, Martin, Graw, Jochen
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876282/
https://ncbi.nlm.nih.gov/pubmed/30991053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2019.03.024
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