An Extended Helical Conformation in Domain 3a of Munc18-1 Provides a Template for SNARE (Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Complex Assembly

Munc18-1, a SEC1/Munc18 protein and key regulatory protein in synaptic transmission, can either promote or inhibit SNARE complex assembly. Although the binary inhibitory interaction between Munc18-1 and closed syntaxin 1 is well described, the mechanism of how Munc18-1 stimulates membrane fusion rem...

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Main Authors: Parisotto, Daniel, Pfau, Maximilian, Scheutzow, Andrea, Wild, Klemens, Mayer, Matthias P., Malsam, Jörg, Sinning, Irmgard, Söllner, Thomas H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2014
Ábhair:
Cell Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975013/
https://ncbi.nlm.nih.gov/pubmed/24532794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.514273
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