Toll-like Receptor 4-mediated Endoplasmic Reticulum Stress in Intestinal Crypts Induces Necrotizing Enterocolitis

The cellular cues that regulate the apoptosis of intestinal stem cells (ISCs) remain incompletely understood, yet may play a role in diseases characterized by ISC loss including necrotizing enterocolitis (NEC). Toll-like receptor-4 (TLR4) was recently found to be expressed on ISCs, where its activat...

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Auteurs principaux: Afrazi, Amin, Branca, Maria F., Sodhi, Chhinder P., Good, Misty, Yamaguchi, Yukihiro, Egan, Charlotte E., Lu, Peng, Jia, Hongpeng, Shaffiey, Shahab, Lin, Joyce, Ma, Congrong, Vincent, Garrett, Prindle, Thomas, Weyandt, Samantha, Neal, Matthew D., Ozolek, John A., Wiersch, John, Tschurtschenthaler, Markus, Shiota, Chiyo, Gittes, George K., Billiar, Timothy R., Mollen, Kevin, Kaser, Arthur, Blumberg, Richard, Hackam, David J.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2014
Sujets:
Molecular Bases of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975009/
https://ncbi.nlm.nih.gov/pubmed/24519940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.526517
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