Proteolysis of Apolipoprotein A-I by Secretory Phospholipase A(2): A NEW LINK BETWEEN INFLAMMATION AND ATHEROSCLEROSIS

In the acute phase of the inflammatory response, secretory phospholipase A(2) (sPLA(2)) reaches its maximum levels in plasma, where it is mostly associated with high density lipoproteins (HDL). Overexpression of human sPLA(2) in transgenic mice reduces both HDL cholesterol and apolipoprotein A-I (ap...

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Bibliographic Details
Main Authors: Cavigiolio, Giorgio, Jayaraman, Shobini
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Lipids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974973/
https://ncbi.nlm.nih.gov/pubmed/24523407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.525717
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