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Structural Basis for PI(4)P-Specific Membrane Recruitment of the Legionella pneumophila Effector DrrA/SidM

Recruitment of the Legionella pneumophila effector DrrA to the Legionella-containing vacuole, where it activates and AMPylates Rab1, is mediated by a P4M domain that binds phosphatidylinositol 4-phosphate [PI(4)P] with high affinity and specificity. Despite the importance of PI(4)P in Golgi traffick...

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Main Authors: Del Campo, Claudia M., Mishra, Ashwini K., Wang, Yu-Hsiu, Roy, Craig R., Janmey, Paul A., Lambright, David G.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974903/
https://ncbi.nlm.nih.gov/pubmed/24530282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.12.018
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