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The Mechanism of Gene Targeting in Human Somatic Cells
Gene targeting in human somatic cells is of importance because it can be used to either delineate the loss-of-function phenotype of a gene or correct a mutated gene back to wild-type. Both of these outcomes require a form of DNA double-strand break (DSB) repair known as homologous recombination (HR)...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3974634/ https://ncbi.nlm.nih.gov/pubmed/24699519 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004251 |
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