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Mutations to Ku Reveal Differences in Human Somatic Cell Lines

NHEJ (non-homologous end joining) is the predominant mechanism for repairing DNA double-stranded breaks in human cells. One essential NHEJ factor is the Ku heterodimer, which is composed of Ku70 and Ku86. Here we have generated heterozygous loss-of-function mutations for each of these genes in two d...

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Detalhes bibliográficos
Main Authors: Fattah, Kazi R., Ruis, Brian L., Hendrickson, Eric A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427147/
https://ncbi.nlm.nih.gov/pubmed/18387344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2008.02.008
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