Translational control by adenovirus: lack of virus-associated RNAI during adenovirus infection results in phosphorylation of initiation factor eIF-2 and inhibition of protein synthesis.

The dl331 mutant of adenovirus serotype 5 fails to produce virus-associated (VA) RNAI, and cells infected with this mutant do not synthesize proteins efficiently at late times in infection. The translational defect occurs at the level of polypeptide chain initiation, and cell-free extracts prepared...

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Detalles Bibliográficos
Main Authors: Siekierka, J, Mariano, T M, Reichel, P A, Mathews, M B
Formato: Artigo
Idioma:Inglês
Publicado: 1985
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC397459/
https://ncbi.nlm.nih.gov/pubmed/3856874
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