Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα

Phosphatidylinositol 4-kinase IIα (PI4KIIα), a membrane-associated PI kinase, plays a central role in cell signalling and trafficking. Its kinase activity critically depends on palmitoylation of its cysteine-rich motif (-CCPCC-) and is modulated by the membrane environment. Lack of atomic structure...

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Detalhes bibliográficos
Main Authors: Zhou, Qiangjun, Li, Jiangmei, Yu, Hang, Zhai, Yujia, Gao, Zhen, Liu, Yanxin, Pang, Xiaoyun, Zhang, Lunfeng, Schulten, Klaus, Sun, Fei, Chen, Chang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974213/
https://ncbi.nlm.nih.gov/pubmed/24675427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4552
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