Determining immune components necessary for progression of pigment dispersing disease to glaucoma in DBA/2J mice

BACKGROUND: The molecular mechanisms causing pigment dispersion syndrome (PDS) and the pathway(s) by which it progresses to pigmentary glaucoma are not known. Mutations in two melanosomal protein genes (Tyrp1( b ) and Gpnmb( R150X )) are responsible for pigment dispersing iris disease, which progres...

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Bibliographic Details
Main Authors: Nair, K Saidas, Barbay, Jessica, Smith, Richard S, Masli, Sharmila, John, Simon WM
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974199/
https://ncbi.nlm.nih.gov/pubmed/24678736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2156-15-42
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