Gpnmb(R150X )allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma

BACKGROUND: The Gpnmb gene encodes a transmembrane protein whose function(s) remain largely unknown. Here, we assess if a mutant allele of Gpnmb confers susceptibility to glaucoma by altering immune functions. DBA/2J mice have a mutant Gpnmb gene and they develop a form of glaucoma preceded by a pig...

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Bibliografiske detaljer
Main Authors: Anderson, Michael G, Nair, K Saidas, Amonoo, Leslie A, Mehalow, Adrienne, Trantow, Colleen M, Masli, Sharmila, John, Simon WM
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373794/
https://ncbi.nlm.nih.gov/pubmed/18402690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2156-9-30
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