Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma

Here, we use a mouse model (DBA/2J) to readdress the location of insult(s) to retinal ganglion cells (RGCs) in glaucoma. We localize an early sign of axon damage to an astrocyte-rich region of the optic nerve just posterior to the retina, analogous to the lamina cribrosa. In this region, a network o...

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Bibliographische Detailangaben
Hauptverfasser: Howell, Gareth R., Libby, Richard T., Jakobs, Tatjana C., Smith, Richard S., Phalan, F. Campbell, Barter, Joseph W., Barbay, Jessica M., Marchant, Jeffrey K., Mahesh, Nagaraju, Porciatti, Vittorio, Whitmore, Alan V., Masland, Richard H., John, Simon W. M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2007
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373494/
https://ncbi.nlm.nih.gov/pubmed/18158332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200706181
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