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Oxygen and the copper chaperone CCS regulate posttranslational activation of Cu,Zn superoxide dismutase

Oxidative stress leads to the up-regulation of many antioxidant enzymes including Cu,Zn superoxide dismutase (SOD1) via transcriptional mechanisms; however, few examples of posttranslational regulation are known. The copper chaperone for SOD1 (CCS) is involved in physiological SOD1 activation, and i...

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Bibliografiske detaljer
Main Authors: Brown, Nina M., Torres, Andrew S., Doan, Peter E., O'Halloran, Thomas V.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC397415/
https://ncbi.nlm.nih.gov/pubmed/15064408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401175101
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