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Oxygen and the copper chaperone CCS regulate posttranslational activation of Cu,Zn superoxide dismutase

Oxidative stress leads to the up-regulation of many antioxidant enzymes including Cu,Zn superoxide dismutase (SOD1) via transcriptional mechanisms; however, few examples of posttranslational regulation are known. The copper chaperone for SOD1 (CCS) is involved in physiological SOD1 activation, and i...

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Brown, Nina M., Torres, Andrew S., Doan, Peter E., O'Halloran, Thomas V.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2004
Aiheet:
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397415/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15064408/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0401175101
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