The BRCA1 Variant p.Ser36Tyr Abrogates BRCA1 Protein Function and Potentially Confers a Moderate Risk of Breast Cancer

The identification of variants of unknown clinical significance (VUS) in the BRCA1 gene complicates genetic counselling and causes additional anxiety to carriers. In silico approaches currently used for VUS pathogenicity assessment are predictive and often produce conflicting data. Furthermore, func...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Christou, Charita M., Hadjisavvas, Andreas, Kyratzi, Maria, Flouri, Christina, Neophytou, Ioanna, Anastasiadou, Violetta, Loizidou, Maria A., Kyriacou, Kyriacos
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2014
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973689/
https://ncbi.nlm.nih.gov/pubmed/24695549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093400
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia