Homozygous mutation of MTPAP causes cellular radiosensitivity and persistent DNA double-strand breaks

The study of rare human syndromes characterized by radiosensitivity has been instrumental in identifying novel proteins and pathways involved in DNA damage responses to ionizing radiation. In the present study, a mutation in mitochondrial poly-A-polymerase (MTPAP), not previously recognized for its...

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Main Authors: Martin, N T, Nakamura, K, Paila, U, Woo, J, Brown, C, Wright, J A, Teraoka, S N, Haghayegh, S, McCurdy, D, Schneider, M, Hu, H, Quinlan, A R, Gatti, R A, Concannon, P
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973239/
https://ncbi.nlm.nih.gov/pubmed/24651433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.99
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