Blocks to thyroid cancer cell apoptosis can be overcome by inhibition of the MAPK and PI3K/AKT pathways

Current treatment for recurrent and aggressive/anaplastic thyroid cancers is ineffective. Novel targeted therapies aimed at the inhibition of the mutated oncoprotein BRAF(V600E) have shown promise in vivo and in vitro but do not result in cellular apoptosis. TNF-related apoptosis-inducing ligand (TR...

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Autors principals: Gunda, V, Bucur, O, Varnau, J, Vanden Borre, P, Bernasconi, M J, Khosravi-Far, R, Parangi, S
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973207/
https://ncbi.nlm.nih.gov/pubmed/24603332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.78
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