Blocks to thyroid cancer cell apoptosis can be overcome by inhibition of the MAPK and PI3K/AKT pathways

Current treatment for recurrent and aggressive/anaplastic thyroid cancers is ineffective. Novel targeted therapies aimed at the inhibition of the mutated oncoprotein BRAF(V600E) have shown promise in vivo and in vitro but do not result in cellular apoptosis. TNF-related apoptosis-inducing ligand (TR...

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Detalhes bibliográficos
Main Authors: Gunda, V, Bucur, O, Varnau, J, Vanden Borre, P, Bernasconi, M J, Khosravi-Far, R, Parangi, S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973207/
https://ncbi.nlm.nih.gov/pubmed/24603332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.78
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