Aldosterone Induces Apoptosis in Rat Podocytes: Role of PI3-K/Akt and p38MAPK Signaling Pathways

BACKGROUND: Podocytes play a critical role in the pathogenesis of glomerulosclerosis. Increasing evidence suggests that aldosterone (ALD) is involved in the initiation and progression of glomerular damage. It is, however, unknown whether there is a direct injurious effect of ALD on podocytes. Theref...

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Bibliographic Details
Main Authors: Chen, Cheng, Liang, Wei, Jia, Junya, van Goor, Harry, Singhal, Pravin C., Ding, Guohua
Format: Artigo
Language:Inglês
Published: S. Karger AG 2009
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790761/
https://ncbi.nlm.nih.gov/pubmed/19590239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000228080
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