The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity

Apoptosis of pancreatic beta cells is a feature of type 2 diabetes and its prevention may have therapeutic benefit. High glucose concentrations induce apoptosis of islet cells, and this requires the proapoptotic Bcl-2 homology domain 3 (BH3)-only proteins Bim and Puma. We studied the stress pathways...

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Главные авторы: Wali, J A, Rondas, D, McKenzie, M D, Zhao, Y, Elkerbout, L, Fynch, S, Gurzov, E N, Akira, S, Mathieu, C, Kay, T W H, Overbergh, L, Strasser, A, Thomas, H E
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2014
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973197/
https://ncbi.nlm.nih.gov/pubmed/24625983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.88
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